Immunosuppressive and Cytotoxic Potential of Flavonoids from Medicinal Plants: Preliminary Investigation for Anticancer Activity

Introduction: Attention related to scientifi c and research interest towards naturally derived compounds from medicinal plant products as they are considered to have less toxic side effects as compared to current treatments such as chemotherapy. Medicinal plant produces naturally occurring secondary metabolites especially fl avonoids which are being investigated for their anticancer activities leading to the development of new clinical drugs. Objective- In this regard, immunological studies were conducted to investigate its immunosuppressive and cytotoxic activity of fl avonoids from the leaves of Calotropis gigantea, Adhatoda vasica and Artocarpus integrifolia on human whole blood and peripheral blood mononuclear cells (PBMC) against hepatitis B vaccine containing surface antigen (HBsAg).