HER2 Status in Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and Review of the Literature
Journal: Journal of Surgery and Surgical Research (Vol.1, No. 3)Publication Date: 2015-12-17
Authors : Meriem N Mrabent Noria Harir Feriel Sellam Soumia Zeggai Abdenacer Tou Mustapha Diaf Rachida Salah; Soraya Moulesshoul;
Page : 049-052
Keywords : Breast cancer; Man; Overexpression; ER; PR; HER2;
Abstract
Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer. Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2. Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study.
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