The Effect on Gastric Emptying of Telaprevir-Based Triple Therapy for Chronic Hepatitis C Patients
Journal: Archives of Clinical Gastroenterology (Vol.1, No. 1)Publication Date: 2015-08-28
Authors : Arata Oyamada Makoto Arai Tomoaki Matumura Kenichiro Okimoto Shoko Minemura Keiko Saito Daisuke Maruoka Tomoo Nakagawa Tatsuo Kanda Tatsuro Katsuno; Osamu Yokosuka;
Page : 009-013
Keywords : Gastric emptying; Hepatitis C; Telaprevir; Interferon;
Abstract
Aim: We evaluated food intake in telaprevir-based triple therapy (telaprevir, pegylated-interferon, and ribavirin) and its relation to Gastric Emptying (GE). Methods: 17 patients received telaprevir combined with pegylated interferon plus ribavirin. The GE study was carried out using the 13C-acetate breath test and GE time was expressed as the peak time of 13CO2 excretion (Tmax). Results: The average food intake was 1,851 ± 91, 1,338 ± 537 and 1,453 ± 537 kcal at 0, 1, and 2 weeks after the start of treatment, respectively, showing a significant decrease compared to that before treatment (p < 0.01 and p <0.05, paired t-test). The averages of Tmax values at 0, 1, and 2 weeks after the start of treatment were 48.4 ± 14.3 min, 56.9 ± 18.4 min and 58.0 ± 19.9 min, respectively. There was a significant difference between baseline and 1 week after the start of treatment (p<0.05, paired t-test). Food intake (kcal) showed a good correlation with the decrease of Tmax values (minutes) (Pearson's correlation test, r = -0.49, p < 0.05).
Other Latest Articles
- Beta-(1,3/1,6)-D-glucan Helps to Decrease Opportunistic Infections in Crohn's Disease Patients Treated with Biological Therapy
- Implementation and Implication of Ignoring Small Polyps at Colonoscopy
- Retrograde Amnesia and Disorientation after Intraocular Injection of Anti-VEGF Agents
- Vitamin -D Deficiency: A Clinical Problem Searching For Solution
- Assessment of Biofield Energy Healing Based Vitamin D3 Effects on Bone Health Parameters Using Human Osteoblast Cell Line (MG-63)
Last modified: 2018-09-04 14:04:56