Acute Effect of Aliskiren on Smoking-Induced Endothelial Dysfunction in Smoker

Background: We aimed to examine the acute effect of aliskiren on smoking-induced endothelial dysfunction in smoker. Methods: Nineteen male smokers were enrolled. After all participants smoked a cigarette, their endothelial function was assessed with brachial artery flow mediated dilation (FMD). An hour after the administration of aliskiren, they smoked again, their FMD was assessed again. A month later, all measurements were performed again without the administration of aliskiren as a control. Blood pressure, plasma renin activity, and serum interleukin-6 concentration were also examined at the same time of FMD measurement.