Tetrahydrobiopterin Concentrations in Normal and Coronary Artery Diseased Heart Tissue
Journal: Journal of Cardiovascular Medicine and Cardiology (Vol.3, No. 1)Publication Date: 2016-06-29
Authors : Erland Arning Brian D Lowes Matthew RG Taylor Xingli Meng Raphael Schiffmann; Teodoro Bottiglieri;
Page : 014-017
Keywords : Tetrahydrobiopterin; Dihydrobiopterin; Coronary artery disease and nitric oxide synthase; Endothelial nitric oxide synthetase; BH4: Tetrahydrobiopterin;
Abstract
Tetrahydrobiopterin (BH4) is an essential cofactor that controls the enzymatic activity of aromatic amino acid hydroxylases as well as all forms of nitric oxide synthase (NOS), which include endothelial (eNOS), neuronal (nNOS) and inducible (iNOS) isoforms [1]. In coronary arteries, reduced availability of BH4 in the endothelium causes decreased production of nitric oxide and an increase in eNOSderived production of reactive oxygen species including superoxide anion and hydrogen peroxide [2,3]. Studies have demonstrated that oxidative stress causes uncoupling of eNOS and endothelial dysfunction, which is associated with chemical inactivation of BH4 and its oxidation to dihydrobiopterin (BH2) [4]. There is mounting evidence that this mechanism plays a particularly important role in coronary artery disease (CAD).
Other Latest Articles
- Atherosclerotic Monstrous Double Aneurysm of the Left Main Coronary Artery: A Very Rare Angiographic Finding
- Lactate Dehydrogenase is involved in but not the Target Antigen in Children with Kawasaki Disease
- Oxidative Stress as "Mother" of Many Human Diseases at Strong Clinical Impact
- Numerical Analysis of Arterial Plaque Thickness and its Impact on Artery Wall Compliance
- Autonomic Innervation from the Aortic Root Ventricular Ganglionated Plexi to the Pulmonary Vein: A Novel Pathway
Last modified: 2018-09-05 14:44:35