The Changes of Myocardium in Minipigs after Coronary Vein Ligation Observed by Transmission Electron Microscopy

Background: The study of coronary artery disease has been quite thorough. But there is few study on coronary vein disease. In clinical practice, some patients have suspicious symptoms of coronary artery disease without any evidence of coronary artery spasm, but coronary angiography showed no obvious stenosis in coronary artery. It may have relationship to coronary venous dysfunction. This study aims to develop a coronary vein ligation model, to investigate the effect of coronary vein occlusion on myocardial cells in normal miniature pigs.