Differential Gastrointestinal Effects of Who-Step III Opioids in Low Back Pain Patients with vs. Without Constipation: Post-Hoc Analysis of Data from a 12-Week Prospective, Open-Label Blinded Endpoint Streamlined Study
Journal: Global Journal of Anesthesiology (Vol.2, No. 2)Publication Date: 2015-12-10
Authors : Michael A Ueberall Gerhard HH Mueller-Schwefe;
Page : 037-051
Keywords : Chronic pain; Constipation; Bowel function; Quality-of-life; Oxycodone; Naloxone;
Abstract
Objective: Opioid-induced constipation (OIC) is the most prevalent patient complaint associated with longer-term opioid use and interferes with analgesic efficacy, functionality, quality-of-life, and patient compliance. To compare effects of prolonged release (PR) oxycodone and PR naloxone (OXN), vs. PR oxycodone (OXY) vs. PR morphine (MOR) on bowel function under real-life conditions in chronic low back pain (LBP) patients with vs. those without pre-existent constipation.
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