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Differential Gastrointestinal Effects of Who-Step III Opioids in Low Back Pain Patients with vs. Without Constipation: Post-Hoc Analysis of Data from a 12-Week Prospective, Open-Label Blinded Endpoint Streamlined Study

Journal: Global Journal of Anesthesiology (Vol.2, No. 2)

Publication Date:

Authors : ;

Page : 037-051

Keywords : Chronic pain; Constipation; Bowel function; Quality-of-life; Oxycodone; Naloxone;

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Abstract

Objective: Opioid-induced constipation (OIC) is the most prevalent patient complaint associated with longer-term opioid use and interferes with analgesic efficacy, functionality, quality-of-life, and patient compliance. To compare effects of prolonged release (PR) oxycodone and PR naloxone (OXN), vs. PR oxycodone (OXY) vs. PR morphine (MOR) on bowel function under real-life conditions in chronic low back pain (LBP) patients with vs. those without pre-existent constipation.

Last modified: 2018-09-06 14:59:12