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SYNTHESIS AND ANTIMICROBIAL ACTIVITY HYBRID SYSTEMS WITH PYRAZOLE, OXADIAZOLE AND THIOPHENE RINGS
Journal: Young Scientist (Vol.5, No. 7)Publication Date: 2017-07-01
Authors : Panasenko N.V.;
Page : 1-4
Keywords : hybrid structures; 3-(4-pyrazolyl)-5-(1; 2; 4)-oxadiazolyl acetonitriles; 4-pyrazolyl-5-(1; 2; 4)- oxadiazolyl-3-thienylamines; cyclocondensation; antimicrobial activity.;
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Abstract
By cyclocondensation of 4-pyrazolylamidooximes with N-cyanoacetyl-3,5-dimethylpyrazole 3-(4-pyrazolyl)- 5-(1,2,4-oxadiazolyl)acetonitriles were synthesized. By interaction of these compounds with sulfur and cycloalkanones in the conditions of Gewald reaction hybrid structures with pyrazole, 1,2,4-oxadiazole and aminothiophene nuclei were produced.
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Last modified: 2018-09-08 02:36:12