Synthesis, Characterization and Evaluation of Antibacterial Activity of a New Phenylmethylidene Thiourea Derivative and Its Copper (Ii) Complex

A new thiourea derivative was synthesized by the condensation reactions of thiourea with benzaldehyde in ethanol. The copper complex was prepared from the reactions of the copper chlorides with newly synthesized phenylmethylidene thiourea derivative. The progress of the reaction was monitored by TLC using water - ethanol as solvent for every 30 minutes. The new ligand and its copper complex were characterized by UV- Visible spectroscopy and IR spectroscopy. The melting point of the synthesized ligand and it copper complex were determined and conductivity of the complex was measured. Synthesized ligand and the complex were screened for antimicrobial activity against two bacteria strains Escherichia coli, and Staphylococcus aureus using agar diffusion disc method.