Association of inflammation with endothelial dysfunction in pregnancy induced hypertensive women

Introduction: Pregnancy induced hypertension is considered as the major cause of maternal and perinatal mortality. Even though occurrence of PIH is due to abnormal placentation, endothelial dysfunction (ED) plays a pivotal role in the genesis of the multisystem disorder that develops in pre eclampsia and eclampsia. Excessive inflammation might lead to ED. So, a study has been designed to analyse some inflammatory markers (TNF-?, HsCRP, IL-6) and their association with endothelial dysfunction (NO) in PIH women. Materials and Methods:Study group consisted of Normotensive pregnant women (N) preclamptic women (PE) and eclamptic women (E) with 100 subjects in each group in the 3rd trimester of pregnancy. They were investigated for TNF-?, IL-6, HsCRP & NO. Statistical analysis was done using ANOVA Results:When compared to controls TNF-?, IL-6, HsCRP levels were found to be significantly high & NO levels were significantly low in PE, E group. Eclamptic women showed a significantly high level of TNF-?, and low levels of NO when compared to PE group. Conclusion:Early careful monitoring of TNF-? along with NO might be helpful to predict the origination and advancement of the disease. It may help in emerging approaches for diagnosis and prevention of maternal and fetal complications.