SPECIFIC INFLAMMATORY PROTEINS IN THE BLOOD AND URINE OF PATIENTS WITH RECURRENT PYELONEPHRITIS

The aim of our study was to investigate the content of specific inflammatory proteins (C-reactive protein, fibronectin, cystatin C) in the blood and urine ofpatients with pyelonephritis, depending on the frequency of recurrences. Patients and methods. A cross-sectional study was carried out and included 64 female patients with uncomplicated pyelonephritis, over 18 years (mean 32.3 ± 9 years). We determined C-reactive protein (CRP), fibronectin (FN), and cystatin C CysC) in the blood and urine of patients using test kits «Dialab» (Austria) by immunoturbidimetric method. After the examination patients were divided into II groups: I (n = 34) – women with recurrent pyelonephritis and II (n = 30) – patients with sporadic pyelonephritis (up to 2 times per year). Results. The patients of group I showed the highest level of blood concentrations of CysC (p = 0.02) and a decrease of FN (p = 0.01). We found an inverse correlation between the number of recurrences of pyelonephritis per year and the blood level of FN (r = -0.42, p = 0.007). In addition, we determined a strong direct correlation between the urinary FN and blood level of CysC (r = 0.6, p <0.0001). Conclusions. Decrease of FN and growth of CysC in the blood ofpatients with recurrent pyelonephritis is the result offrequent inflammatory activity. Determination of specific inflammatory proteins in the blood and urine ofpatients with pyelonephritis can be used as alternative markers for diagnosis and monitoring of disease