IMMUNE STATUS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACCOMPANIED WITH CHRONIC KIDNEY DISEASE AND METABOLIC DISTURBANCES

The chronic kidney disease (CKD) is often accompanied to the chronic pulmonary disease (COPD) III stage and metabolic syndrome, (MS) which is because to the persistence of arterial hypertension and disturbances in hydrocarbon metabolism. Materials and methods. There were examined the 52 patients with III stage COPD, combined with MS, aged 51,3±4,2 years old, among them 23 with COPD, combined with MS and CKD I-IIstage (the main group). The compared group was included the 29 patients with COPD, combined with MS, without signs CKD. The all persons were examined by immunology investigation with the detection of cell and humoral immunity indexes and cytokine level. Results and discussion. The breath function data's, the arterial hypertention stage and level did not have the significant differences. All the patients had the creatinine clearance not less than 60 ml/min/1,73m2. The detection of immune status shows the decrease of T-cell amount, especially the T-cytotoxical lymphocytes/ supressors, the significantly increase level ofactivated Tcells with early activated markers, those, which expressed adhesion molecule ICAM-1 and FAS- receptor, autoimmune and inflammatory changes in blood serum. Conclusions. The available ofСKD in patients COPD, combined with MS, initiated the more high activity of system immune inflammation in atherosclerosis manifestation as the morphological substrate of MS.