ANTIOXIDANT EFFECTOF NUCLEINAT SODIUM IN PATIENTS WITH CHRONIC KIDNEYDISEASE І–II STAGES: UNCOMPLICATED PYELONEPHRITIS

Objective: to determine the antioxidant effects of Nucleinat sodium in patients with uncomplicated recurrent pyelonephritis. Material and methods. We have analyzed the indicators of oxidant/ antioxidant (O/ A) balance in the blood of 55 patients with uncomplicated recurrent pyelonephritis. Women were randomized into 2 groups: I (n=30) consisted of patients treated with Nucleinat sodium at a dose of 0.25 mg 4 times daily for 14 days to II (n=25) included patients who used only antibacterial therapy (according to the set sensitivity identified pathogens). The control group consisted of 20 conditional healthy donors, matched for sex and age. Results. In the blood ofpatients prior to treatment were observed reduction of total peroxidase activity of red blood cells (p<0.0001), ceruloplasmin (p=0,03), SH–groups (p=0.001) and increase in serum MDA, and oxidative stress index (p<0.0001) compared with the conditionally healthy donors. Comprehensive treatment with Nucleinat sodium statistically significantly led to normalization of these parameters and decrease of urine N–acetyl–p–D– glucosaminidase and p–galactosidase (p<0,001 and p=0.04, respectively). Conclusions. For the treatment of uncomplicated recurrent pyelonephritis appropriate to apply Nucleinat sodium at a dose of 0.25 mg 4 times / day, which helps to reduce the activity of oxidative processes and the negative impact of oxidative stress on the patient, and increases of antioxidant protection.