MICROBIOCENOSIS IN CHILDREN WHITH CHRONIC RECURRENT PYELONEPHRITIS

Introduction — the leading mechanism of the kidney infections is the lymphogenous pathogen migration associated with translocation from the mesenteric lymph nodes and blood stream. Reduction in the number of bifidobacteria in the bifidobacteriaenterobacteria balance is an adverse prognostic factor of probably bacteria persistence in the urinary system. The aim of our study was to compare the urine microflora with the microbiocenosis of the intestinal mucous membrane as well as of the nose and throat mucosa in children with recurrent pyelonephritis (PN). Material and methods. Qualitative and quantitative investigation of the microbiological spectrum was per- fomed. In patients with the revealed e. coli the intestinal biocenosis was compared with the biocenosis of the nose and throat mucousa. The repeteated examination of the urine and feces was conducted in 12patients after the probiotic treatment. Results. The predominance of E. coli and conditionally pathogenic microorganismus in the urine tests for patients with chronic PN in active stage as well as in remission coincided with the indicators of the intestine biocenosis. Consistently high inoculation of S. aureus in the nasopharynx of children with acute and chronic PN correlated with the presence of this agent in the urine and feces. Prolonged use of probiotics led to decrease ofenterokoccus and eliminated pathogenic enteroflora, as well as to PN remission with lack of intercurrent respiratory infection in the dynamics of observation. Conclusion.Comparison of urine microflora with nasopharigeal mucosa as well as with intestinal mucosa microflora in patients with recurrent chronic PN gives the opportunity to predict the clinical bechaviour and to correct individually the treatment using probiotics whith antirecurrent purpose.