In-Vitro α-Amylase Screening and Molecular Docking Studies of Theophylline Derivatives as Anti-Diabetic Agents

α-amylase of theophylline derivatives was rarely explored despite these agents have diverse pharmacological activities. The in vitro α-amylase inhibitory activity of the theophylline compounds Va-e were evaluated using acarbose as standard positive control. The IC50 values of these compounds were ranged from 26.89-60.82 µg/ml. All the compounds have exhibited good interactions with α-amylase target 4GQR and have good correlation with biological activity