INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS
Journal: Ukrainian Journal of Nephrology and Dialysis (Vol.4, No. 40)Publication Date: 2013-12-05
Authors : I. Dudar; V. Drijanska; E. Grigorjeva; J. Gonchar; E. Krasjuk;
Page : 30-33
Keywords : haemodialysis; inflammation; nutrition; interleukin; IL-10; albumin;
- INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS
- Can body shape index indicate obesity-associated inflammation and cardiovascular diseases in stage 3-4 chronic kidney disease patients?
- Investigating the relationship between the level of serum albumin and body mass index, as nutritional indicators, with dialysis adequacy in patients under hemodialysis
- Factors related to the progression of Chronic Kidney Disease after two years of follow-up of stage 3 Chronic kidney Disease Patients
- Association of serum uric acid level and body mass index between non alcoholic fatty liver disease patients and healthy volunteers
Abstract
IL-10 - one of the central factors in the altered cytokine network of uremia, may play important role in the development of T-helper imbalance, CVD and wasting in dialysis patients. Aim: to evaluate level of ІL-10 in CKD stage 5D patients depending on the body mass index and serum albumin. Methods: Thirty-nine HD patients were included (male/female 20/19, age 21- 53 years, mean dialysis treatment time 4.2 ± 1.21 years). Blood tests were taken before a midweek dialysis session. Serum IL-10, serum albumin and BMI were measured. Results: HD patients had higher serum IL-10 than healthy donors (79.9 ± 7.3 vs. 18.8 ± 1.3 pg/ml, p < 0.001). Patients with low BMI had lower serum IL-10 than patients with normal BMI and large BMI – 31.0 ± 6.3 pg/ml; 76.7 ± 10.1 pg/ml; 117.7 ± 6.2 pg/ml, respectively (p < 0.001). Higher IL-10 was associated with increased serum albumin. Conclusion: Compensative increase of anti-inflammatory cytokine IL-10 in serum is typical in HD patients. Patients with nutrition deficit are characterized by lower serum IL-10.
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