INFLUENCE OF GLICEROL ON FUNCTIONAL-MORPHOLOGICAL INDICATORS OF KIDNEYS AT MODELLING RENAL INSUFFICIENCY IN RATS

It is known, that after acute damage of kidney there is a risk of development of chronic kidney desease and death rate from its complications. Material and methods. Research are spent on 40 not purebred rats at modelling of acute damage of the kidneys caused by toxic doses of glycerol. To evaluate histopathologal changes , we used cuts of fabrics painted gematoksilin- eozinom. Ultrathin preparations analyzed in electronic microscope PЕМ-125К. Results. Administration of glycerol leads to uremia with dystrophic changes in tubular device and glomerular hypertrophy. At a stage of chronic renal insufficiency reduction of the glomerular sizes, tubulointerstitial fibrosis and glomerulosclerosis is observed. Conclusion. At modelling of a nephritic pathology by introduction of 50 % glycerol infringement of function of kidneys has phasic character with probable development of chronic kidney desease in 8 weeks.