Short-Term Effects of Pre/Probiotics on P-Cresol and Indoxyl-Sulphate Serum Concentrations During the Various Stages of Chronic Kidney Disease
Journal: Archives of Renal Diseases and Management (Vol.3, No. 1)Publication Date: 2017-06-19
Authors : Filomena Panza Diletta Duranti Ralli Chiara Matteo Basile Marco Bagnati Giorgio Bellomo; Ennio Duranti;
Page : 001-005
Keywords : ;
Abstract
Background:The uremic syndrome is provoked by a progressive number of compounds that are normally excreted by kidneys in healthy individuals. Indoxylsulphate (IXS) and p-cresylsulphate (PCS), have been found increased in subjects with end stage renal disease (ESRD) creating great harm to biological systems; these uremic toxins come from the intestinal bacterial fermentation of the proteins.The aim of our study is to evaluate the short-term effects after an administration of pre / probiotics in CKD patients, regarding the production and then the serum concentrations of free IXS and PCS (i.e. non-protein bound fraction) and total IXS and PCS ( i.e. sum of unbound and protein bound fraction).
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