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Short-Term Effects of Pre/Probiotics on P-Cresol and Indoxyl-Sulphate Serum Concentrations During the Various Stages of Chronic Kidney Disease

Journal: Archives of Renal Diseases and Management (Vol.3, No. 1)

Publication Date:

Authors : ; ;

Page : 001-005

Keywords : ;

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Abstract

Background:The uremic syndrome is provoked by a progressive number of compounds that are normally excreted by kidneys in healthy individuals. Indoxylsulphate (IXS) and p-cresylsulphate (PCS), have been found increased in subjects with end stage renal disease (ESRD) creating great harm to biological systems; these uremic toxins come from the intestinal bacterial fermentation of the proteins.The aim of our study is to evaluate the short-term effects after an administration of pre / probiotics in CKD patients, regarding the production and then the serum concentrations of free IXS and PCS (i.e. non-protein bound fraction) and total IXS and PCS ( i.e. sum of unbound and protein bound fraction).

Last modified: 2018-09-17 18:32:22