Effects of Anabolic Androgenic Steroids on Renal Morphology in Rats
Journal: Archives of Renal Diseases and Management (Vol.3, No. 2)Publication Date: 2017-09-26
Authors : Virginia A Aparicio Daniel Camiletti-Moirón Mohammed Tassi Elena Nebot Carlos de- Teresa; Pilar Aranda;
Page : 034-037
Keywords : Corrosive injury; Lye; Acid; Management;
Abstract
Aim: To investigate the long-term effects of anabolic androgenic steroids (AAS) on renal status in rats. Methods: Twenty Wistar rats were distributed into 2 groups: AAS or placebo, for 3 months.The animal received 10mg/kg body weight of Stanozonol once a week by intramuscular injection in the gluteus, or saline solution as placebo. Results: Urinary pH was more acidic in the AAS compared to the placebo group (p<0.05). Kidney weight was 15% higher in the AAS compared to the placebo group (p<0.001). Renal glomerular area was 12% higher in the AAS compared to the placebo group (p=0.001). Animals injected with AAS also displayed a no significant but clinically relevant ~20% higher kidney interstitial connective tissue, glomerular tufts and mesangiums.
Other Latest Articles
- Effectiveness and Tolerability of Febuxostat vs Allopurinol in patients with Chronic Kidney Disease (CKD) on Conservative Therapy
- Factor causing late referral of CKD patients to Nephrology care
- Use of Interpreters for non-native English speaking Kidney Allograft Recipients and outcomes after Kidney Transplantation
- Quality of Life in Patients with Chronic Renal Failure and Some Affecting Factors
- Encapsulating Peritoneal Sclerosis: Different clinical presentations and their management
Last modified: 2018-09-17 18:41:10