Melanocortin-4 Receptor in Fish: A Review

The melanocortin-4 receptor (MC4R) belongs to the melanocortin system, has been well investigated in mammals. Which plays important roles in several physiological processes, such as regulating energy homeostasis, cachexia, cardiovascular function, glucose and lipid homeostasis, reproduction and sexual function, drug abuse, pain perception, brain inflammation, and anxiety. Although there are some studies have performed, its role still remain mystery in fish. This review will summarize the studies on the fish MC4R from its cloning and tissue distribution to its physiological roles. Which should be useful for further studies in fish and might provide a new insight in aquaculture industry.