PARTICIPATION OF THE NITROGEN OXIDE CYCLE IN AUTOIMMUNE COMPONENT FORMATION IN EXPERIMENTAL MODEL OF THE SJÖGREN SYNDROME

In this paper we studied histological changes, ferment strength of nitrogen oxide cycle at 68 rats with the experimental model of the Sjögren syndrome obtained by introduction of mixture of BCG vaccine and glycerin into parotid gland of the rat. The model development is followed by increase of quantity of parotid gland tissues antibodies and at the same time by decrease in number of the CIC, that explains a combination of the increased degeneration of parotid gland at the minimum manifestations of inflammatory reaction. At the same time changes in the nitrogen oxide cycle take place. It is shown by decrease of the NO-synthase activity in parotid gland tissues at simultaneous increase in its activity in the macrophages, which are located in its tissue, and NOх decrease in blood serum.