Monoamine Oxidase Inhibitory and Anticonvulsant Activities of Some Substituted Isatin Semicarbazones

Abstract: Substituted isatin-semicarbazones were synthesized by condensation reaction of appropriate N-substituted-5-(un) substituted isatin with corresponding phenyl semicarbazide and studied for monoamine oxidase (MAO) inhibitory and anticonvulsant activities. In vitro MAO-inhibiting activity was determined by radiometric enzyme assay method in rat liver tissue, and anticonvulsant activity was performed using standard maximal electroshock (MES) induced seizures method in mice. . All of these compounds exhibited MAO inhibiting and anticonvulsant activities, however, there appeared no parallel correlation ship between the activities of these compounds. Thus, these results indicate that MAO inhibiting property does not prove the biochemical basis for the anticonvulsant activity of these compounds. Acute toxicity studies indicate that the compounds have a wide margin of safety.