Simultaneous Estimation of Telmisartan, Hydrochlorothiazide and Amlodipine Besylate in Tablet Preparation by Chemometric Assisted Spectrophotometric Analysis
Journal: Indian Drugs (Vol.55, No. 07)Publication Date: 2018-07-28
Authors : Ghule A. S. Thomas T. Joseph M. Navya Sree K. S.; Bhat K;
Page : 59-66
Keywords : ;
- Simultaneous Estimation of Telmisartan, Hydrochlorothiazide and Amlodipine Besylate in Tablet Preparation by Chemometric Assisted Spectrophotometric Analysis
- UV SPECTROPHOTOMETRIC ABSORPTION CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF OLMESA RTAN MEDOXOMIL, AMLODIPINE BESYLATE AND HYDROCHLOROTHIAZIDE IN COMBINED TABLET DOSAGE FORM
- Simultaneous Determination of Ramipril and Amlodipine Besylate in Tablet Dosage form by First Order Derivative Spectrophotometric Method
- Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Amlodipine Besylate and Candesartan Cilexetil in Synthetic Mixture
- SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND INDAPAMIDE BY DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR COMBINED PHARMACEUTICAL DOSAGE FORM
Abstract
A chemometric method was developed by application of Partial Least Square regression to for the simultaneous estimation of telmisartan, hydrochlorothiazide and amlodipine besylate in tablet preparations. Calibration set was prepared considering seven sets; each set with twenty-four mixed solutions and twenty-one ternary mixed solutions, were prepared as a validation set. The absorbance data matrix for training set was obtained by recording absorbance within wavelength range 220-320 nm at 2nm intervals. The developed method was validated according to ICH Q2 (R1) guidelines and results were reported. The developed and validated multivariate method was successfully tested for laboratory mixtures as well as commercial tablet formulation of telmisartan, hydrochlorothiazide and amlodipine besylate.
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