PREPARATION AND EVALUATION OF FLOATING MATRIX SYSTEM OF LEVOFLOXACIN HEMIHYDRATE TABLETS
Journal: Indian Drugs (Vol.55, No. 08)Publication Date: 2018-08-28
Authors : Baratam S. R.; Jayanthi V. R.;
Page : 67-70
Keywords : ;
Abstract
Gastro floating drug delivery system (GFDDS) of Levofloxacin hemihydrate (LVF), category of Quinoline antibiotic used to treat Helicobacter pylori infection. The aim of the study was to develop a Floating matrix system (FDDS) of LVF for sustained release to improve the extended retention in stomach and local site specific action in the stomach. Preparation of LVF tablets using wet granulation method using HPMC K4M with Sodium bicarbonate as effervescent agent. All formulations were developed and evaluated for Floating properties for swelling characteristics and in vitro drug release studies. In vitro drug release were performed and drug release kinetics were evaluated by using linear regression method and was found to be follow zero order release with diffusion controlled release. Optimized formula was found to be LFTA4 with 20% of polymer with 99.03% of drug release with 12 hours of Floating time and 32 seconds floating lag time. The obtained FT-IR charts indicated that there is no positive evidence for the interaction between LVF and ingredients of the optimized formula.
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