The research advancement of fibroblast on diabetic non-healing skin wound

The delayed wound healing especially non-healing skin wound is one of the problem in clinical practice and hot research in basic medicine. The common therapies' effects were not confirm. The induced Pluripotent Stem Cell (iPSC) technology is one of de novo approaches in regeneration medicine these years. The original iPSC was reprogrammed from rat tail fibroblast. So the concept of direct cellular reprogramming was reported versus the iPSC-based reprogramming. Thus we review the fibroblast potential “stem” characteristics and its promotion to the wound healing.