Second Trimeter Recurrent Pregnancy Loss in Women with History of PCOS

Recurrent pregnancy loss (RPL) is one of the most frustrating and difficult areas in reproductive medicine because the etiology is often unknown. Hyper insulinemia ascribed to PCOS and insulin resistance (IR) seem to be a contributing factor to RPL. The aim of this study was to assess the relationship between serum homocysteine level and insulin resistance in PCOS women with a history of send trimester recurrent pregnancy loss. The present study was carried out on 100 non-pregnant women in the reproductive period; their age ranged from 20 to 35 years. They were classified under two groups: Group 1: women having a history of second trimester recurrent pregnancy loss with PCOs (60 women). Group 2: women having a history of second trimester recurrent pregnancy loss and non-PCOs (40 women).