Lack of Association between the 4234G/C X-Ray Repair Cross- Complementing 2 (XRCC2) Gene Polymorphism and the Risk of Endometrial Cancer among Polish Population

Objective: One of the major causes of carcinogenesis is loss of genome stability. The double strand break DNA repair pathway, including X-ray repair cross complementing group 2 (XRCC2) gene, is implicated in maintenance integrity of genome and therefore could affect endometrial cancer (EC) risk. The purpose of this study was to evaluate the clinical significance of the XRCC2 4234G/C (rs3218384) gene single nucleotide polymorphism (SNP) in endometrial cancer patients. Material and Methods: The study included 1632 patients: 808 with endometrial cancer and 824 healthy controls. XRCC2 4234G/C (rs3218384) polymorphism was genotyped by the PCR-RFLP (restriction fragment-length polymorphism) method. The associations of the analysed genotypes and clinical data at diagnosis have been evaluated.