Distribution and immunoexpression of LOX, PCP and Myofi broblasts in Vaginal Tissue of Postmenopausal Women with and without Pelvic Organ Prolapse

Aim: of the study was to investigate the difference of distribution and expression of the lysyl oxidase enzymes (LOX), the pro-collagen C proteinase (PCP) and the myofibroblasts in the vaginal tissue of postmenopausal women, with and without prolapse. Materials and Methods: This was a prospective closely matched controlled clinicopathological study. Samples were obtained from the anterior vaginal wall of postmenopausal patients that underwent hysterectomy for benign conditions. The immunohistochemical study of the samples was performed on paraffin embedded specimens with the semi-automatic Ventana method according to the manufacturer's instructions. We have also examined the correlation between prolapse and parity, age and body weight in the same population.