Can the response to three months Ibuprofen for controlling Heavy Menstrual Bleeding with IUD be predicted at baseline visit?

Objective: The present study examines the hypothesis that the clinical and ultrasonography data reported at baseline visit can predict the responsiveness of ibuprofen in controlling heavy menstrual bleeding with Cu-IUDs at 3 months follow-up visit. Materials and methods: We used data revealed from a single center open label prospective cohort study conducted at Woman's Health Hospital, Assiut University, Egypt in the period between the 1st of October 2015 and the 30th of September 2016. This study included 128 women complaining of heavy/ prolonged menstrual bleeding with Cu-IUD; they received ibuprofen for three consecutive cycles. Seventy patients (54.68%) respond to ibuprofen and while 58 patients (45.31%) did not respond. Logistic regression was done to show the signifi cant predictors of ibuprofen response and a receiver operating characteristic (ROC) curves was used to evaluate the sensitivity and specifi city of the potential predictors revealed by logistic regression