HOMEOSTASIS OF DIGESTIVE ENZYMES IN CHILDREN WITH ATOPIC DERMATITIS

The aim of the study is to characterize the homeostasis of digestive enzymes in atopic dermatitis in young children. The material and methods. The study included 128 children aged from 8 months to 2 years with severe extended atopic dermatitis. In patients with atopic dermatitis in periods of exacerbation of the disease and clinical remission, the content of pepsinogen, amylase, lipase, alkaline phosphatase, aspartate - aminotransferase and alanine - aminotransferase in serum, urine and coprofiltrate were studied, the functional activity of hemo -renal and hemo - instestinal barriers in relation to these enzymes was evaluated. The results. In children with atopic dermatitis during the exacerbation of the disease, there were stated functional disorders of the digestive system, and it is manifested in pronounced changes in the content of hydrolases and amino - transferases in biological media, disorder of functional activity of hemo - renal and hemo - intestinal barriers against digestive enzymes. Changes in the homeostasis of digestive enzymes are found in child ren with atopic dermatitis and in the period of clinical remission, although they are less pronounced than in the period of exacerbation of the disease.