Renal FGFR1 signaling and blood pressure regulation

FGF-23 is a bone-derived hormone that regulates phosphate and vitamin D homeostasis through activation of FGFR/α-Klotho binary receptor complexes in the kidney. The association between elevated circulating FGF-23 concentrations and increased cardiovascular mortality, particularly in chronic kidney disease (CKD), has brought new interest in understanding FGF-23's on-target and off-target cardiovascular actions. Preclinical data indicates that FGF-23 administration to mice elevates blood pressure and causes left ventricular hypertrophy (LVH), but the mechanisms mediating FGF-23's hemodynamic effects and cardiotoxicity are the subject of controversy and debate. In this mini review, the role of FGF-23 and FGFR1 signaling in regulation of hemodynamic is discussed.