Different Levels of Exhaled Nasal Nitric Oxide in Patients Diagnosed with Primary Dyskinesia
Journal: Archives of Pulmonology and Respiratory Care (Vol.1, No. 1)Publication Date: 2015-11-17
Authors : A Bodini D Peroni L Tenero M Sandri M Brunelli G Inzalaco U Pradal M Piazza AL Boner; GL Piacentini;
Page : 014-017
Keywords : Nasal nitric oxide; Primary ciliary dyskinesia; Kartagener’s syndrome;
Abstract
Background: Primary ciliary dyskinesia (PCD) is a genetic disease characterized by abnormally beating cilia. In these patients levels of nasal nitric oxide (nNO) are lower than those observed in healthy subjects. Objectives: We recorded the nNO levels in PCD patients in order to use those nNO measurements in the screening and identification of patients with symptoms suggestive of disease PCD disease. Methods: We measured nasal NO in 36 PCD patients (3 uncooperative younger children and 33 cooperative adult patients) and did a nNO re-evaluation after 12 months in patients with higher levels of nNO. Results: Twenty-seven PCD patients showed very low nNO levels (29.1 ppb) and nine cooperative patients had high nNO levels (583.3 ppb, p<0.001) (T0); the PCD patients with high nNO levels were re-evaluated after 12 months (T1). The median T0 and T1 nNO values of the seven PCD patients were 360 ppb and 324 ppb(p=0.0180), respectively; in 6 patients with high levels of nNO the diagnosis of PCD was confirmed byelectron microscopy, and in one subject the diagnosis was confirmed for secondary ciliary dyskinesia.
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