Relationship of coronary collateral development with mean arterial pressure in patients with stable coronary artery disease

Aims: The prognostic value of blood pressure and the association between these parameters and cardiovascular conditions have been established in literature. In this study, we aimed to investigate the correlation between peripheral blood pressure parameters with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical artery stenosis. Methods: A total of 363 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: group with adequate CCD (n=120) and group with inadequate CCD (n=243). Peripheral blood pressure parameters were evaluated before coronary arteriography. Results: Peripheral diastolic blood pressure (DBP) and mean arterial pressure (MAP) levels were significantly higher in the inadequate CCC group (81.5±10.7 vs 77.9±9.9, p=0.02 and 100.6±11.8 vs 96.6±9.3, p<0.001). In Pearson's correlation analysis revealed that, Peripheral DBP and MAP levels were significantly correlated with Rentrope Collateral Grading (r= 0.26, p<0.003 and r=0.29, p<0.001, respectively). ROC curve analysis of MAP and DBP for prediction of inadequate. At the cut-off value of > 99,8mmHG, sensitivity and specificity of MAP were 57% and 69%, respectively. At the cut-off value of >79,5 mmHg, sensitivity and specificity of DBP were 72% and 42%, respectively. Conclusion: The present study suggests that peripheral DBP and MAP levels may be associated with degree of collateral development in chronic stable CAD. Low peripheral DBP and MAP in the case of severe coronary stenosis in stable CAD may be an important stimulus for coronary collateral development.