Zaragozic Acid A Enhances the Internalization of VLDL in Human Hepatocyte-Like C3A Cells
Journal: Aperito Journal Of Cellular And Molecular Biology (Vol.1, No. 1)Publication Date: 2014-10-24
Authors : Soumya Ivaturi Catherine J Wooten; Dayami Lopez;
Page : 1-9
Keywords : LDL; VLDL; LDL receptor; Zaragozic Acid A; Hepatic cells;
Abstract
High Low Density Lipoprotein (LDL) cholesterol levels are well-known to cause atherosclerotic diseases. The hepatic LDL receptor is the major determinant of plasma LDL-cholesterol levels, and as a result, a greater understanding of the regulatory mechanisms that control the expression and function of this gene is essential. Herein, we decided to examine whether the function of the LDL receptor increased in response to the cholesterol biosynthesis inhibitor, Zaragozic Acid A (ZA), which has been shown to significantly decrease serum cholesterol levels in rats. The results demonstrated that ZA increased the binding and internalization of Very Low Density Lipoprotein (VLDL), but not of LDL. This ZA-dependent increase in the internalization rate of VLDL was unrelated to an increase in the overall expression levels of the LDL receptor at the cell surface. These results suggest that ZA could reduce plasma cholesterol levels by preventing the synthesis of LDL from VLDL.
Other Latest Articles
- Senile Transthyretin Cardiac Amyloidosis in Patients with Plasma Cell Dyscrasias: Importance of Cardiac Biopsy for Making The Correct Diagnosis
- Planning of the Geographic Information System Application to Agricultural Land Use
- Sumo-2/3 and Rnf4 Localization to DNA Replication Foci in Cultured Human Cells Over expressing the P150 Subunit of Chromatin Assembly Factor 1
- Palliative Care” – Not Just Simple Words
- Design of Two-Wheeled Ultrasonic Wheel
Last modified: 2018-10-04 14:15:09