Role of microRNA-7-1-3p in Prostate Cancer Progression

Prostate cancer (PCa) is one of the most common malignant diseases in western world and now emerging as a challenging disease in developing countries. Although much progress has been done to control of androgen sensitive PCa in recent years, the early diagnosis and treatment for Prostate cancer are not yet satisfactory and, thus the metastatic progression control/treatment is still poor. MicroRNAs (miRNAs) are well known regulatory factor of physiological and developmental processes, it has been revealed that many miRNAs contribute the initiation and progression of various cancers. In the present preliminary study, we evaluated the expression status of miR-7-1-3p on normal prostate cell line (PNT1A), androgen sensitive prostate cancer cell line (LNCaP) and androgen insensitive prostate cancer cell lines (DU145). The results of this study revealed that miR-7-1-3p was upregulated in metastatic form of prostate cancer cell line DU145, but no changes were noticed in miR-7 expression on other cell lines (LNCaP and PNT1A). Thus our preliminary studies suggested that miR-7-1-3p may serve as a novel microRNA for the diagnosis and as a new therapeutic target in prostate cancer.