Is there a Place for Case Reporting in a Randomized Controlled Trial Era?

The case report is the written mirror of a striking duality: the low level of evidence supported by a single case and the scientific breakthrough of someone's judge when facing something new. The knowledge-box is well defined in every textbook or main article we may find. However, when confronted to the unknown or unexplained, this box can only support the jump to the unknown as it doesn't contain all the answers. Only the continuous restlessness of an unconfirmed clinician is able to achieve new answers and throw the first basis of a new development – the Case Report (CR).