In Three Cases, the Use of Dabigatran was Found to be Associated with Factor VIII Inhibitors and Prolonged APTT

We report the use of dabigatran was found to be associated with Factor VIII inhibitors and prolonged APTT in the three cases. Taking the dabigatran was recognized prolonged APTT, low titer Factor Ⅷ inhibitors and reduction of Factor Ⅷ. Once these cases stopped dabigatran in a variety of causes. At the time of dabigatran discontinuation, APTT was normal value and Factor Ⅷ, Factor Ⅷ inhibitor became the normal value. When dabigatran resumed. APTT was prolonged and low titer Factor Ⅷ inhibitors and reduction of Factor Ⅷ. Side effects of bleeding at the time of APTT prolongation was not admitted in three cases.