Antibiotic Resistance Pattern of Urinary Catheter Biofilm and Urine - in Tertiary Care Hospital, Bangladesh

Catheter-Associated Urinary Tract Infection (CAUTI) is common worldwide health care associated problem. Antibiotic resistance in CAUTI is due to wide spread use of urinary catheter and inappropriate use of antibiotics. The present study highlights the trend of organism and their resistance patterns. This observational prospective study was done on 100 CAUTI patients in Comilla medical college hospital, Comilla, Bangladesh. Urine culture positive patients collected by suprapubic puncture meet the criteria of CAUTI with formation of biofilm in catheter was selected. E.coli was the most frequently isolated pathogen in both urine and biofilm (60% vs.72%) followed by Klebsiella and others. Biofilm strains displayed relatively high resistance against tested antibiotics. The E.coli in both urine and biofilm shows high resistance against ciprofloxacin and cotrimoxazole (80%& 65% vs 84% & 82% respectively), and low for imipenem and amikacin (5% and 18% vs 8% and19% respectively). Urine and catheter biofilm resistant to all tested drugs was observed for E.coli in 6.95% and 3.33% cases respectively. E.coli was the most frequent isolate followed Klebsiella and others. E. coli in both urine and biofilm showed the high resistance to the quinolones and cotrimoxazole and low for carbapenems and amikacin.