2015 ACR/SLICC Revised Criteria for Diagnosis of Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune systemic disorder with unknown etio-pathogenesis. Upon the susceptible genetic, hormonal and abnormal immunologic background, the environmental factors especially ultraviolet rays may play role as trigger to permit disease development [1]. Auto-antibodies especially Antinuclear Antibodies (ANA), antidouble stranded DNA (anti-dsDNA), anti-smith antibody (antiSm), anti-phospholipid antibodies (aPLs), antibodies against RBC, WBC, platelets, anti-neuronal antibodies and consumption of complements and production of Immunecomplexes can contribute to creation of all clinical/laboratory manifestations of SLE [2, 3].