Pies and Fires Activate PAI-1 in Obesity and Diabetes Type 2

Obesity is a global problem and is reaching pandemic proportion over the world. The supporting statistics are alarming and are indicating that the obesity and diseases associated with it will be one of the biggest public health challenges of the 21st century. This condition like many others is the result of interplay between genetic and environmental factors. Mutation in more than forty genes controls appetite and metabolism that predispose to obesity if sufficient food energy is delivered. In the last fifty years average per capita energy consumption rose from 2250 kcal to over 2750 kcal. This increase was partially due to reduction of hunger in many parts of the world but also substantially due to consumption of high energy food such as pies, fries and high sugar drinks