The Genetic Dosage Imbalance Linked to Clinical Brain Alterations and Mental Disability in Down Syndrome Could be Targeted for Therapeutics Development

Trisomy of human chromosome 21 is a major cause of Mental Disability and other clinical phenotypic abnormalities such as hypotonia, skeletal and heart defects, immunological and haematological defects, collectively known as Down syndrome, affecting 1/700 live births.