Antimicrobial activities of Carica papaya leaf against diarrhoea causing agents

The advent of science to the search for antibiotics principally depends on medicinal plants as raw materials. This present study evaluated the antimicrobial effect of Carica papaya leaf extracts against bacterial and fungal agents that causes diarrhoea. Fresh tender roots and leaves of this plant was collected, air-dried, powdered and percolated in n-hexane, methanol and aqueous solvents. The antimicrobial activities of the extract against test organisms were tested by using agar well diffusion assay and the MIC, MBC and MFC values were determined by agar dilution assay. The results revealed that the crude methanol and aqueous extracts of Carica papaya had no anti-fungal activity, but have antibacterial activity. N.hexane extract of C. papaya had most activity than other solvents with MIC ranged from 25 mg/ml to 50 mg/ml and MBC ranged from 50 mg/ml to 100 mg/ml.These results suggest that paw paw leaf extract is recommended as a diarrhoea disease remedy.