Subsistence of Host Guest Inclusion Complexes ofBiologically Active Moleculeswith Ionic Liquid Probed by Physicochemical Exploration

In this present work we studied the supramolecular interaction of 1-hexyl-3-methylimidazolium hexaflurophosphate(HMIm)PF6with α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) using various physicochemical method and spectroscopic technique. The formation of inclusion complex of any ionic liquid inside the cyclodextrin affects the physicalchemical properties like solubility, conductivity, surface tension, etc. So rom the discrepancy of physicochemical andspectral properties we can confirm the formation inclusion complex. The stoichiometry of host - guest of the inclusion complexes was evaluated from conductivity, surface tensionstudy and Job's plot from UV-visible spectroscopy. We also calculated the association/binding constant from conductivity, surface tension measurements and Benesi-Hildebrand equation. The infra-red (IR) and 1H NMR spectroscopy also affirm the formation of inclusion complexes however the plausible mode of inclusion was described from 1H NMR and 2D ROESY NMR spectroscopies.