Exercise-induced time-dependent changes in plasma BDNF levels in people with schizophreniaExercise-induced time-dependent changes in plasma BDNF levels in people with schizophrenia

Objective: To investigate the short and long-term outcomes of a concurrent exercise protocol (CEP) on plasma Brain-derived neurotrophic factor (BDNF) levels and the effect of this intervention in the self-esteem and mental health in people with schizophrenia (SZ). Methods: In this quasi-experimental study, 15 participants underwent a structured, supervised and group based CEP for 12 weeks (the sessions were performed 3 times a week for 60 minutes). In order to verify the short- and long-term effects of exercise on BDNF levels, blood samples of 15 ml were collected pre-intervention and on the 4th, 8th and 12th week(s) after intervention started. To evaluate self-esteem, the Rosemberg Self-esteem Scale was used, and the general mental health status was measured through the General Health Questionnaire-12 (GHQ-12). Both questionnaires were applied before and after intervention.