SYNTHESIS AND ANTI-DIABETIC ACTIVITY OF SOME ARYLOXYPROPANOLAMINE DERIVATIVES

Journal: Indian Drugs (Vol.55, No. 10)

Publication Date: 2018-10-29

Authors : Puranik H. H.; Jadhav S. B.; Bandawane D. D.; Bhalekar P. A.;

Page : 16-23

Keywords : * For Correspondence: E-mail: sbjadhav_pharma@yahoo.co.in;

Source : Download Find it from : Google Scholar

Abstract

Aryloxypropanolamine plays an important role in several biological activities. It shows multiple actions such as β-blocking, anxiolytic, antihypertensive and inhibition of cytochrome p450. A series of ten aryloxypropanolamine derivatives 6a–6j were synthesized and evaluated for anti-diabetic activity. Two compounds 6b to 6g have shown good anti-diabetic activity. All synthesized compounds (6a-6j) were evaluated for their anti-diabetic activity in STZ induced diabetes model of Wistar rats.

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SYNTHESIS AND ANTI-DIABETIC ACTIVITY OF SOME ARYLOXYPROPANOLAMINE DERIVATIVES

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