Effect of mifepristone in cervical ripening for induction of labour
Journal: International Journal of Reproduction, Contraception, Obstetrics and Gynecology (Vol.2, No. 1)Publication Date: 2013-03-01
Authors : Rutuja Athawale Neema Acharya S. Samal C. Hariharan;
Page : 35-38
Keywords : Mifepristone; Induction of labour; RU486;
Abstract
Background: Mifepristone is potentially a method of inducing labour in late pregnancy by increasing uterine contractility and by increasing the sensitivity of the uterus to the actions of prostaglandins. Present study was done to portrait the beneficial of mifepristone induction of labour. The objective was to study the effect of mifepristone in induction of labour with the outcome of induction of labour (IOL). Methods: 100 patients (term) were included, after their informed consent. Patients were categorized by BISHOP SCORE at the beginning of induction for comparison of BS, mode of delivery, induction delivery interval (IDI). Women undergoing induction with RU486 (200mg PO) were grouped in one and those with placebo control group into another. Statistical analysis of categorical variables was done. Results: Rate of successful IOL or vaginal delivery was 76% in study group and only 36% in control group. After induction with mifepristone for cervical ripening in study group 76% patient who had cervical score 8 within 24 hours, whereas in control group 2% female’s cervical score was>8. Among the babies, 44% in the control group required baby unit admission as compared to 36% in the study group. Conclusions: In the present study, the women who were induced with mifepristone 200 mg per orally showed drastic improvement in cervical score within 24-48 hours and decreased the cesarean rate in the study group and amount of dose requirement of augmentation of labour with Misoprostol or Oxytocin, lesser NICU admission and maternal complication. [Int J Reprod Contracept Obstet Gynecol 2013; 2(1.000): 35-38]
Other Latest Articles
- Comparison of efficacy of labetalol and methyldopa in patients with pregnancy-induced hypertension
- Pregnancy outcome after diagnosis of oligohydramnios at term
- Outcome of post caesarean pregnancy and comparison of maternal and foetal outcome following vaginal birth versus repeat caesarean section in a rural hospital
- Delayed re-laparotomy after total hysterectomy
- A study to evaluate the relationship between socio-economic, demographic characteristics and complications of acceptors in double puncture laparoscopic and conventional tubal ligation procedures
Last modified: 2013-03-26 10:56:17