EFFECT OF SODIUM CARBONATE, ERUCA SATIVA OIL, LAVENDER OIL AND ALOE VERA OIL ON LIVER IN BREAST CANCER INDUCED FEMALE RATS TREATED WITH DOXORUBICIN

Background:Natural products like Eruca sativa,Aloe vera and lavender oils includes many antioxidants like isothiocyanates and flavonoids and vitamins in addition sodium carbonate is an alkaline material which used to alter the acidic medium of the cells. The previous natural products used to treat many diseases especially tumors Adriamycin is a chemical substance used to treat breast cancer but it is probably have side effects. The aim of the work is studying effect of Eruca sativaoil, lavenderoil,Aloe Vera oil and sodium carbonate on rat's liver that treated with Adriamycin after breast cancer induction. Materials and methods: thirty female albino rats were divided to sex groups, negative control, positive control, sodium carbonate group, Eruca sativa oil group , lavender oil group and Aloe Vera oil groups all groups except negative control are cancer induced with MCF7 cell line; all groups except negative control and positive control are Adriamycin treated the experiment was extended for one month the rats were sacrificed and serum is analyzed in addition to liver tissues were fixed and sectioned then stained and examined by light microscope. Results: ANOVA show significant changes in total bilirubin, direct bilirubin, SGPT, and SGOT in serum of different treated group but on the liver tissue liver of sodium carbonate group shows destructed hepatocytes around the portal vein