Role of Microbes Relating to Hygiene Hypothesis and Effect of Microbe Symbiosis on the Human Health- A Review

Since the microbes and humans have co-evolved with each other, so, the coexistence between them is key for survival on earth. With the emergence of concept that all microbes are germs in germ theory given by Robert Koch, the humans headed towards a lifestyle where hygienic environment became synonymous to the sterile environment. This eventually led to some unintended consequences. The millennial generation witnessed increased cases of allergic, atopic and autoimmune disorders. Interestingly, these cases are not uniformly distributed across the world. Rather, there is an uneven geographic distribution of these cases. The cases are more prevalent in developed urbanised areas compared to underdeveloped rural areas. The occurrence of these diseases is attributed to immune dysregulation occurring in the body. The uneven interactions between the microbes and the immune cells result in an exaggerated hypersensitive IgE mediated immune response which result in the diseases. The present review aims to discuss the role of microbes pertaining to hygiene hypothesis and the effect of microbe symbiosis on the human health. Rishabh Jain "Role of Microbes Relating to Hygiene Hypothesis and Effect of Microbe Symbiosis on the Human Health- A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-6 , October 2018, URL: http://www.ijtsrd.com/papers/ijtsrd18821.pdf