Formulation Development and Evaluation of Ondansetron Hcl Fast Dispersing Tablets for Treatment of Chemotherapy

The objective of the present investigation is to prepare fast dispersing tablets of ondansetron hydrochloride, because of its application in emesis condition, fast onset of action and avoidance of water is highly desirable. Tablets are prepared by direct compression of sodium starch glycolate, croscarmellose sodium and combination of both are used as superdisintegrants. Microcrystalline cellulose is used as binder and mannitol used as dilluent and sodium saccharin used as sweetening agent and magnesium stearate used as lubricant. All these ingredients are mixed together and compressed into tablets. Before punching into tablets the powder is evaluated for bulk density, tapped density, angle of repose and Carr’s index. After punching the tablets are evaluated for weight variation, hardness, friability, in vitro disintegration time, wetting time, and drug release characteristics. Hardness and friability data indicated good mechanical strength of tablets. The results of in vitro disintegration time indicated that the tablets dispersed rapidly in mouth within one minute. It was also observed that the ondansetron hydrochloride prepared tablets drug releasing rate is faster than the pure drug. It is also concluded the order of drug releasing rate was found to be faster in case of tablets prepared by combination of super disintegrates < sodium starch glycolate < croscarmellose sodium.