Efficacy of Subcutaneous Tocilizumab for the Treatment of Refractory Large Vessel Vasculitis in a Patient with Latent Tuberculosis Infection

Tocilizumab (TCZ), a specific IL-6 inhibitor, has been shown to be effective and well tolerated in the treatment of refractory large-vessel vasculitis with monthly intravenous (i.v) infusions of 8 mg/Kg of body weight. Our case report has confirmed the efficacy of TCZ also if administered subcutaneously (s.c.) in a patient with large-vessel vasculitis resistant to a combination of corticosteroids (CST) plus methotrexate (MTX). Moreover, reactivation of latent tuberculosis was not observed in our case with isoniazid prophylaxis.